Jurgen Klopp has made four changes to the side that beat Napoli in midweek, with some of those forced changes due to injuries. Clyne makes his first appearance of the season at right-back, with Lovren partnering Van Dijk at centre-back. Keita and Fabinho also come in the starting XI, replacing Henderson and Milner in midfield. Meanwhile for United, the big news is that Pogba does not start for the visitors, the Frenchman is on the bench. Mourinho has made 10 changes to the side that were beaten by Valencia, with United appearing to line-up up in a 3-5-2 formation, that may revert to a five at the back if Liverpool start to pile on the pressure.
United have won just one of their last four matches in all competitions and they sit sixth in the table with 26 points, 16 points behind Liverpool. Mourinho does have a good record of winning at Anfield, securing four victories out of his eight visits with Chelsea and United. They were beaten 2-1 at Valencia in the Champions League on Wednesday, however, they did still progress to the knockout stages of the competition as runners-up in their group.
UNITED SUBS: Sergio Romero, Phil Jones, Antonio Valencia, Marouane Fellaini, Paul Pogba, Juan Mata, Anthony Martial
UNITED (3-5-2): David De Gea; Victor Lindelof, Eric Bailly, Matteo Darmian; Diogo Dalot, Nemanja Matic, Ander Herrera, Jesse Lingard, Ashley Young; Marcus Rashford, Romelu Lukaku.
LIVERPOOL SUBS: Simon Mignolet, Alberto Moreno, Rafael Camacho, Jordan Henderson, Adam Lallana, Xherdan Shaqiri, Daniel Sturridge.
LIVERPOOL (4-3-3): Alisson Becker; Nathaniel Clyne, Dejan Lovren, Virgil Van Dijk, Andrew Robertson; Fabinho, Georginio Wijnaldum, Naby Keita; Sadio Mane, Roberto Firmino, Mohamed Salah